The CoaguChek® systems

Learn more about the CoaguChek® systems

Whether in the clinic or at home, INR control with the CoaguChek® systems is simple, reliable, and safe.


CoaguChek® INRange System

A new option for patient self-testing

CoaguChek® XS

For patient self-testing

CoaguChek® Pro II system

A new option for point-of-care testing

CoaguChek® XS Pro system

For point-of-care INR testing

Frequently asked questions concerning CoaguChek® products

At least twice per month, but preferably once per week. This has proven to increase time in therapeutic range (TTR) by enabling faster reactions to variations in INR due to exercise and diet. It also increases patient compliance and engagement.1–3

TTR is the percentage of time that your patient’s INR values fell within the upper and lower target value set by you.

No, calibration is performed automatically upon inserting the code key from the strip vial.

Due to diverse measurement standards used by labs, small variations should be expected. If the variation is of therapeutic significance, please contact your local Roche support organization.

Single sealing of strips is done to prevent moisture and light from affecting the chemistry of the strips, and to maintain a shelf life as long as possible. However, single sealing is less convenient for the customer and more expensive for the manufacturer. Each test strip vial consists of a stopper with desiccant, which protects the test strips from moisture and light.

Polyglobulism: Hematocrit outside the standard range (25%–55%)
Lupus anticoagulant: INR abnormally high
The presence of anti-phospholipid antibodies (APAs) such as lupus antibodies (LA) can potentially lead to prolonged clotting times (i.e., elevated INR values). A comparison to an APA-insensitive laboratory method is recommended if the presence of APAs is known or suspected.

The open vial stability is 10 minutes maximum. Keeping the strip out of the vial for too long, especially in high humidity or temperature, would be detected by the onboard integrity system and result in an error message. No international normalized ratio (INR) would be displayed if the strips are found to be defective by the integrated quality control of the CoaguChek® INRange/XS system.

If the incorrect code chip is in the machine, the prothrombin time (PT)/INR value may be incorrect. Depending on the lot variation, the error can be significant, causing the wrong therapeutic decision to be taken and resulting in an adverse health effect.

CoaguChek® XS, XS Pro, Pro II

Major differences are:

  • Amperometric (electrochemical) detection method instead of dancing particle
  • Size and weight
  • Auto-power on
  • Sample application point outside the meter
  • Infrared interface
  • The existence of professional models: the CoaguChek® XS Plus and Pro

Beside the mentioned technology, the differences are:

  • Top and side dosing capability
  • Strip storage at room temperature
  • Extended % Quick measuring range
  • The low international sensitivity index (ISI) value of 1.0
  • Heparin insensitivity at therapeutic levels
  • The onboard single-channel control (OS2C) system = integrity check on each strip in the same channel where blood passes, which makes it unnecessary to run liquid controls

In the measuring channel, a chemical called resazurin is incorporated. Resazurin is sensitive to ambient factors like light, humidity, and temperature, leading to a reaction process where resazurin is converted into resorufin. The concentration of resorufin is measured electrochemically, and the result is a direct measure of strip alteration.

The fill of the capillary is detected by a current flow between two electrodes on the test strip. If the capillary is not completely filled, an error message (error number 5) will appear on the display.

CoaguChek® XS

Never add more blood to the test strip after the test has begun or perform another test with blood from the same puncture site. Yes, re-dosing is possible within 15 seconds. However, in principle, re-dosing is very critical due to the immediate start of the coagulation process. Therefore, this should be avoided if possible.

CoaguChek® XS Plus, XS Pro, Pro II

Yes, re-dosing is possible within 15 seconds. However, in principle re-dosing is very critical due to the immediate start of the coagulation process. Therefore, this should be avoided if possible.

CoaguChek® XS

An error message (error number 4) will appear on the screen.

CoaguChek® XS Pro, Pro II

An error message will appear on the screen.

The user can erase the entire memory. A user cannot, however, erase individual results.

The meter has a built-in internal quality control so liquid controls are not needed.

In principle, yes. However, the CoaguChek® XS Pro system is a much more suitable solution in a professional setting due to the data management capabilities created for professionals:

  • Positive strip lot identification
  • The ability to input patient and operator ID to facilitate record keeping
  • Touchscreen
  • A search function for patient data in the memory

The CoaguChek® XS Pro system is the ideal choice for you when accuracy and ease of use need to be combined with data management.

Coaguchek Pro II

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